Explanation

The Suez Canal is correct because its blockage significantly disrupts major global shipping lanes. The Strait of Malacca is incorrect because while important, the question points to a specific historical/major disruption often associated with the canal. The Indus River is incorrect because it is an inland river and not a primary international trade chokepoint like the others listed. The Red Sea is incorrect because the Suez Canal's blockage is the more direct and historically cited cause for massive global economic losses in this context.