A pure drug is administered as a sphere and as a cube. The amount of drug is the same in the two tablets. Assuming that the shape and size do not influence the mass transfer, the ratio of rate of dissolution in water at t = 0 for the cubic to spherical tablet is___________________?

Question

Accepted Answer

1.24. The dissolution rate is proportional to the surface area. The ratio of surface areas for a cube and a sphere with the same volume is $\frac{6}{ \sqrt[3]{2\pi}} \approx 1.24$.